Xin Lu

Sylvia Xin

Solid-state nanofluidic devices have proven to be ideal systems to elucidate the physics of nanoscale ion transport. When the device confinement approaches the Debye length of ions in the fluid, new phenomena occur such as surface-charge-dominated transport and ion-selectivity. Although these effects have been understood for simple monovalent systems, application-critical divalent systems have ...

Ting - Xin Jiang

Xin Scaffolding Proteins and Arrhythmias.

Intercalated disc (ICD), a unique specialized structure in cardiac muscle, transmits mechanical force and electrical impulses among cardiomyocytes. Recent studies also suggest that ICD, via scaffolding/anchoring proteins, can spatially organize and maintain key ion channel assemblies required for controlling the cardiac action potential. Defects in these processes can lead to arrhythmias and ca...

Organization of the Human LU Gene and Molecular Basis of the Lu/Lu Blood Group Polymorphism

The Lutheran (Lu) blood group antigens and the B-cell adhebut includes several potential binding sites for the ubiquitous Sp1 transcription factor. In addition, the distal 5* region, sion molecule (B-CAM) epithelial cancer antigen are carried by recently cloned integral glycoproteins that belong to the encompassing nucleotidesÏ673 toÏ764, contains clustered binding sequences for the GATA, CACCC...

MicroRNA-218 is a prognostic indicator in colorectal cancer and enhances 5-fluorouracil-induced apoptosis by targeting BIRC5 Pei-Long Li† Xin Zhang† Li-Li Wang, Lu-Tao Du, Yong-Mei Yang, Juan Li and Chuan-Xin Wang*

One major reason for the failure of advanced colorectal cancer (CRC) treatment is the occurrence of chemoresistance to fluoropyrimidine (FU)-based chemotherapy. Various reports showed that ectopic expression and function of microRNAs (miRNAs) played key roles to mediate apoptosis at the post-transcriptional level. To further explore the possible mechanisms, we evaluated the prognostic effect of...